the lipophilicity examination of some ace inhibitors and hydrochlorothiazide on cellulose in rp thin-layer chromatography
نویسندگان
چکیده
in this assay, the evaluation of lipophilicity of four ace-inhibitors and hydrochlorothiazide (hctz) with rp-tlc on cellulose layers was described using three binary solvent systems. the selected ace inhibitors had sufficiently different structures which can indicate the method suitability for their lipophilicity evaluation as the model substances in comparison with hctz. in addition, the linear relationship between the rm-values and composition of mobile phases was established in the current study. from the regression data of the plots, the hydrophobicity parameters, r and m, were determined and c0 parameter was calculated. the correlations between the experimentally obtained hydrophobicity parameters and calculated log p values were studied. furthermore, the obtained results were compared with those previously obtained on rp-18 modified silica gel. very good correlation (r = 0.91; water-ethanol solvent system) between the chromatographically obtained hydrophobicity parameters and calculated log p values confirmed the selection of ace inhibitors since lisinopril and quinapril were on the opposite sites of linear relationship. the results indicate that cellulose as an easily available sorbent can be successfully used for the lipophilicity investigation of examined substances with rp-tlc.
منابع مشابه
The Lipophilicity Examination of Some ACE inhibitors and Hydrochlorothiazide on Cellulose in RP Thin-Layer Chromatography
In this assay, the evaluation of lipophilicity of four ACE-inhibitors and hydrochlorothiazide (HCTZ) with RP-TLC on cellulose layers was described using three binary solvent systems. The selected ACE inhibitors had sufficiently different structures which can indicate the method suitability for their lipophilicity evaluation as the model substances in comparison with HCTZ. In addition, the linea...
متن کاملThe Lipophilicity Examination of Some ACE inhibitors and Hydrochlorothiazide on Cellulose in RP Thin-Layer Chromatography
In this assay, the evaluation of lipophilicity of four ACE-inhibitors and hydrochlorothiazide (HCTZ) with RP-TLC on cellulose layers was described using three binary solvent systems. The selected ACE inhibitors had sufficiently different structures which can indicate the method suitability for their lipophilicity evaluation as the model substances in comparison with HCTZ. In addition, the linea...
متن کاملLipophilicity Examination of Some ACE inhibitors andHydrochlorothiazide on Cellulose in RP Thin-Layer Chromatography
In this assay, the evaluation of lipophilicity of four ACE-inhibitors and hydrochlorothiazide (HCTZ) with RP-TLC on cellulose layers was described using three binary solvent systems. The selected ACE inhibitors had sufficiently different structures which can indicate the method suitability for their lipophilicity evaluation as the model substances in comparison with HCTZ. In addition, the linea...
متن کاملQuantitative Analysis of Valsartan and Hydrochlorothiazide in Tablets by High Performance Thin-layer Chromatography
A new, simple, accurate, and precise high-performance thin-layer chromatographic (HPTLC) method has been established for simultaneous analysis of valsartan and hydrochlorothiazide in tablet formulations. Standard and sample solutions of valsartan and hydrochlorothiazide were applied to precoated silica gel G 60 F254 HPTLC plates and the plates were developed with chloroform–ethyl acetate–acetic...
متن کاملon translation of politeness strategies in dialogues involving female characters in translations and retranslations of novels translated before and after the islamic revolution of iran and their effects on the image of women: a polysystem theory approach
abstract reception environment has considerable effects on accepting a translation. as the expectations of a target culture and its values and needs change throughout history, its criteria for accepting a translation or rejecting it will change accordingly (gentzler, 2001). the expectations of iran, as the reception environment in the present study, have changed after the islamic revolution. i...
Identification of some lipid peroxides by thin-layer chromatography.
Solvent systems are described which permit class separations of various peroxidized lipids by thin-layer chromatography. This procedure has proved useful in biological studies and for testing the deterioration of lipids. Proof is given that the least polar peroxides of methyl esters, glycerides, and fatty acids are monoperoxides; it is then assumed that the least polar peroxides in the other te...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
the iranian journal of pharmaceutical researchجلد ۱۱، شماره ۳، صفحات ۷۶۳-۷۷۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023